However, measuring cytotoxicity alone is not sufficient
However, clinical trials are warranted to translate the promising preclinical findings into viable therapeutic approaches for TBI patients
Oh yeah, up the river system
Be aware that B12 injections may cause muscle cramps or weakness
Nevertheless, the convergence of (i) higher baseline CRP among improvers, (ii) the strong correlation with CRP/NLR and MELD, and (iii) the recognised role of glutathione in modulating redox-sensitive inflammatory pathways, does support a biologically coherent hypothesis: glutathione may be most useful in patients with an inflammatory phenotype, where oxidative stress and systemic inflammation are dominant, modifiable drivers of acute decompensation ( FIGURE 8 The apparent counter-intuitive finding that patients with higher baseline MELD, bilirubin, INR and CRP were more likely to improve also fits this picture
Well be doing a deeper dive on specific topics we introduce in this article in subsequent articles in this series
